AI Article Synopsis
- Irradiation-induced tumors are rare but significant, with 14 cases found in 11 patients at the hospital over 10 years, primarily linked to earlier treatments for conditions like tuberculosis and lupus.
- The time between receiving radiation and developing a tumor varied, averaging 32 years, with most cases being squamous cell carcinomas in the head and neck region.
- The findings stress the importance of carefully considering the risks of radiation therapy in young patients due to the potential, albeit small, risk of inducing cancer.
Article Abstract
Though irradiation-induced tumours are uncommon they represent a well defined entity. At this Hospital, 14 "irradiation-induced" head and neck tumours were encountered in 11 patients over a 10-year period. The irradiation had been given for tuberculous lymph-adenitis in 6 of the patients, for lupus vulgaris in one, and thyrotoxicosis in another; the other 3 patients had received radiotherapy for malignant tumours. The interval between the treatment and the diagnosis of the tumour disease ranged from 9 to 48 years (mean 32). The induced tumours included 10 squamous cell carcinomas of the hypopharynx (4 tumours), the buccal mucosa (3), the skin (2), and the larynx (1), one poorly differented carcinoma of the parotid gland, 2 thyroid carcinomas and 1 fibrosarcoma of the stenocleidomastoid muscle. Three of the patients had multiple tumours. In view of the risk of cancer--albeit a small one--associated with radiological diagnosis and radiotherapy, these should be performed only on strict indications, especially in young patients.
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| http://dx.doi.org/10.3109/00016487809123509 | DOI Listing |
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