Pullulan, one of the commercially important microbial exopolysaccharides, is produced by the yeast like fungus Aureobasidium pullulans. It is non-mutagenic, non-toxic, non-hygroscopic, tasteless, odorless, water soluble and edible polymer. Owing to its excellent film forming properties, and typical rheological properties, it is extensively used in diverse industrial applications that include food, agriculture, textiles, cosmetics and pharmaceuticals. In the recent past, there has been growing interest to produce pullulan from low cost substrates in order to bring down cost of pullulan. The cost, productivity and properties of pullulan are highly influenced by the selection of raw material (upstream processing), type of fermentation & fermentation conditions (bioprocessing) and product recovery steps (downstream processing). In addition, both upstream and bioprocessing also affect the rheological, thermal and physical properties of the product. The present review discusses the literature on upstream processing, bioprocessing, product recovery and applications of pullulan.
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http://dx.doi.org/10.1016/j.carbpol.2017.06.022 | DOI Listing |
Anticancer Agents Med Chem
January 2025
Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Unlabelled: Mesenchymal‒epithelial transition factor (c-Met), a receptortyrosine kinase (RTK), plays a vital role in cell proliferation, migration and invasion, and tumour metastasis.
Objective: With increasing duration of treatment, many tumours gradually develop drug resistance. Therefore, novel antitumour drugs need to be developed to treat patients with tumours.
Hepatic ischemia-reperfusion injury (IRI) poses a significant threat to clinical outcomes and graft survival during hemorrhagic shock, hepatic resection, and liver transplantation. Current pharmacological interventions for hepatic IRI are inadequate. In this study, we identified ginsenoside Rk2 (Rk2), a rare dehydroprotopanaxadiol saponin, as a promising agent against hepatic IRI through high-throughput screening.
View Article and Find Full Text PDFEnviron Sci Ecotechnol
January 2025
Systems Biotechnology Group, Department of Microbial Biotechnology, Helmholtz Centre for Environmental Research - UFZ, 04318, Leipzig, Germany.
Biophotovoltaics (BPV) represents an innovative biohybrid technology that couples electrochemistry with oxygenic photosynthetic microbes to harness solar energy and convert it into electricity. Central to BPV systems is the ability of microbes to perform extracellular electron transfer (EET), utilizing an anode as an external electron sink. This process simultaneously serves as an electron sink and enhances the efficiency of water photolysis compared to conventional electrochemical water splitting.
View Article and Find Full Text PDFFront Cell Dev Biol
December 2024
Biomedical Research Institute of Southern California, Oceanside, CA, United States.
Interferon types-I/II (IFN-αβ/γ) secretions are well-established antiviral host defenses. The human immunodeficiency virus (HIV) particles are known to prevail following targeted cellular interferon secretion. CD4 T-lymphocytes are the primary receptor targets for HIV entry, but the virus has been observed to hide (be latent) successfully in these cells through an alternate entry route via interactions with LFA1.
View Article and Find Full Text PDFJ Cell Sci
January 2025
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
G protein-coupled receptor (GPCR) signalling pathways underlie numerous physiological processes, are implicated in many diseases and are major targets for therapeutics. There are more than 800 GPCRs, which together transduce a vast array of extracellular stimuli into a variety of intracellular signals via heterotrimeric G protein activation and multiple downstream effectors. A key challenge in cell biology research and the pharmaceutical industry is developing tools that enable the quantitative investigation of GPCR signalling pathways to gain mechanistic insights into the varied cellular functions and pharmacology of GPCRs.
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