We analyze the quantum dynamics of periodically driven, disordered systems in the presence of long-range interactions. Focusing on the stability of discrete time crystalline (DTC) order in such systems, we use a perturbative procedure to evaluate its lifetime. For 3D systems with dipolar interactions, we show that the corresponding decay is parametrically slow, implying that robust, long-lived DTC order can be obtained. We further predict a sharp crossover from the stable DTC regime into a regime where DTC order is lost, reminiscent of a phase transition. These results are in good agreement with the recent experiments utilizing a dense, dipolar spin ensemble in diamond [Nature (London) 543, 221 (2017)NATUAS0028-083610.1038/nature21426]. They demonstrate the existence of a novel, critical DTC regime that is stabilized not by many-body localization but rather by slow, critical dynamics. Our analysis shows that the DTC response can be used as a sensitive probe of nonequilibrium quantum matter.
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http://dx.doi.org/10.1103/PhysRevLett.119.010602 | DOI Listing |
J Clin Transl Endocrinol
December 2024
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Thanks to the identification of crucial molecular pathways, the therapeutic landscape for advanced differentiated thyroid tumors (DTCs) has significantly improved during the last ten years. The therapeutic scenario has been greatly impacted by the discovery of mutually exclusive gene changes in the MAPK and PI3K/AKT pathways, such as or fusions and pathogenic mutations of the and genes. Indeed, multi-kinase inhibitors and selective inhibitors have demonstrated outstanding efficacy for radioactive iodine-refractory (RAI-R) drug treatment, with overall response rates reaching up to 86%.
View Article and Find Full Text PDFCureus
November 2024
Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, USA.
Objectives To determine if direct-to-consumer (DTC) laboratory testing is less expensive for patients, as is generally advertised, and whether it has any role in managing uninsured or underinsured patients. Methods The costs of six commonly ordered laboratory tests were obtained through two major DTC laboratories and compared with 42 physician-ordered, hospital-based laboratories in Florida. The costs of DTC tests were also compared to concurrent reimbursements from Medicare and Medicaid.
View Article and Find Full Text PDFCureus
November 2024
Medicine, Hofstra University, Hempstead, USA.
In the thyroid, abnormal growth can be the result of either benign thyroid nodules (BTNs) or differentiated thyroid cancers (DTCs). If the growth is confirmed to be a DTC, surgical intervention, either a partial or total thyroidectomy, is recommended. Although a majority of BTNs do not require treatment, intervention becomes necessary when nodules cause symptoms, enlargement, or a rare suspicion of malignancy.
View Article and Find Full Text PDFMed Phys
November 2024
High-Field and Hybrid MR Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Front Genet
November 2024
Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Introduction: Awareness, access, and use of clinical and direct-to-consumer (DTC) genetic tests has increased in recent years with documented disparities in these services. We provide updated data on test awareness and use, and report novel data on motivations and methods for accessing genetic tests.
Methods: Nationally representative data from the 2022 Health Information National Trends Survey (HINTS 6) were used to assess awareness and use of ancestry, personal trait, specific disease, and carrier testing by sociodemographic characteristics, examine reasons for undergoing tests, and methods of accessing them.
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