The time of occurrence of three stages of hypothermia (mild, moderate and deep with the rectal temperature of 33, 26 and 19 degrees C, respectively) was recorded in acute experiments on rats cooled in water (7 degrees C). It was established that under normothermia aminazine exerted the hypothermic effect and rausedil (24 hrs) the hyperthermic effect. At external cooling both aminazine and rausedil (4 hrs) exhibit the antihypothermic action.
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Pharmacol Toxicol
February 1988
Astra Alab AB, Research and Development Laboratories, Södertälje, Sweden.
In order to study the effects of castration of brain dopamine (DA) receptor sensitivity, the effects of apomorphine on locomotor activity and striatal DA synthesis, as assessed by the dihydroxyphenylalanine (DOPA) accumulation after NSD-1015 treatment, were examined in normal and castrated male Sprague-Dawley rats pretreated with reserpine (5 mg/kg-18 hrs). There was an enhanced locomotor response to apomorphine (0.05-0.
View Article and Find Full Text PDFA "closed space" subarachnoid hemorrhage (SAH) was produced experimentally in cats by rupture of the right middle cerebral artery to test the working hypothesis that a stressful event which provokes powerful sympathoadrenal discharge: causes a massive release of co-stored endogenous enkephalins together with catecholamines, induces an increased rate of opioid peptide precursor processing and/or synthesis, and eventually results in markedly elevated tissue levels of enkephalins relative to controls and to co-stored catecholamines. Adrenal medulla and other tissues were analyzed for met- and leu-enkephalins by RIAs and norepinephrine and epinephrine by HPLC-EC at 4 hrs, 3, 10, 16 and 30 days post-SAH. Catecholamines of adrenal medulla were already decreased at 4 hrs and by 3 days post-SAH depletion of epinephrine reached 86% and norepinephrine 53% compared to controls.
View Article and Find Full Text PDFFarmakol Toksikol
August 1986
The time of occurrence of three stages of hypothermia (mild, moderate and deep with the rectal temperature of 33, 26 and 19 degrees C, respectively) was recorded in acute experiments on rats cooled in water (7 degrees C). It was established that under normothermia aminazine exerted the hypothermic effect and rausedil (24 hrs) the hyperthermic effect. At external cooling both aminazine and rausedil (4 hrs) exhibit the antihypothermic action.
View Article and Find Full Text PDFActivities of alpha-hydroxybutyrate- and lactate dehydrogenases (HBDH, LDH), aspartate- and alanine aminotransferases (AST, ALT), alkaline phosphatase, alpha-amylase as well as content of total proteins, glucose, cholesterol, triglycerides and Ca2+ were estimated sprectrophotometrically in blood serum of rat males within 2 hrs after thermic burns of the III degree involving 15% the body surface. The burns caused about 2-fold increase in activities of LDH, HBDH and AST and in content of triglycerides in blood serum but did not affect the other biochemical patterns. Adrenalectomy, carried out within 3 days before the burns, accelerated and pseudoadrenalectomy decreased the early postburn enzymatic activation.
View Article and Find Full Text PDFWe have developed an assay for serotonin (5-HT) stimulation of adenylate cyclase activity in membranes from adult guinea pig hippocampus. The response to 5-HT is concentration-dependent, with an EC50 of 0.01 microM, a shallow slope, and mean maximal stimulation of 90% over basal activity.
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