Introduction: Memory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown.
Methods: Here, we investigated how differences in free recall performance are associated with DTI-based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner.
Results: Global structural connectivity, but not overall or regional grey matter volumes, positively correlated with recall performance. Moreover, a set of 22 inter-regional connections, including some with no previously reported relation to human memory, such as the connection between the temporal pole and the nucleus accumbens, explained 7.8% of phenotypic variance.
Conclusions: In conclusion, this large-scale study indicates that individual memory performance is associated with the level of structural brain connectivity.
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| http://dx.doi.org/10.1002/brb3.721 | DOI Listing |
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