O'Brien (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741086 | PMC |
| http://dx.doi.org/10.1126/science.aan2396 | DOI Listing |
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