Influence of childhood trauma on diagnosis and substance use in first-episode psychosis.

S Tomassi S Tosato V Mondelli C Faravelli A Lasalvia G Fioravanti C Bonetto A Fioritti C Cremonese R Lo Parrino K De Santi A Meneghelli S Torresani G De Girolamo E Semrov M Pratelli D Cristofalo M Ruggeri

Br J Psychiatry

Simona Tomassi, MD, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona; Sarah Tosato, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona; Valeria Mondelli, MD PhD, Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; Carlo Faravelli, MD, Department of Psychiatry, University of Firenze, Florence; Antonio Lasalvia, MD PhD, Unit of Psychiatry, AOUI, Verona; Giulia Fioravanti, PhD, Department of Psychiatry, University of Firenze, Florence; Chiara Bonetto, PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Angelo Fioritti, MD, Department of Mental Health, Azienda Unità Sanitario Locale (AUSL) Bologna, Bologna; Carla Cremonese, MD, Unit of Psychiatry, Azienda Ospedaliera Padova, Padua; Riccardo Lo Parrino, MD, Department of Mental Health, Florence; Katia De Santi, MD, Unit of Psychiatry, AOUI, Verona; Anna Meneghelli, Ospedale Niguarda Ca' Granda Milano, MHD Programma 2000, Milan; Stefano Torresani, MD, Department of Mental Health, Bolzano; Giovanni De Girolamo, MD, St John of God Clinical Research Centre of Brescia, Brescia; Enrico Semrov, MD, Department of Mental Health, Reggio Emilia; Michela Pratelli, MD, Department of Mental Health, Riccione; Doriana Cristofalo, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Mirella Ruggeri, MD PhD, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, and Unit of Psychiatry, AOUI, Verona, Italy; the GET UP Group.

Published: September 2017

Childhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use.To test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.The sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d. = 9.7).Severe sexual abuse was significantly associated with a diagnosis of affective psychosis (χ = 4.9, = 0.04) and with higher rates of lifetime use of cannabis (68% 41%; = 0.02) and heroin (20% 5%; = 0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% 5%; = 0.03) and cocaine (32% 17%; = 0.05).Patients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.

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http://dx.doi.org/10.1192/bjp.bp.116.194019	DOI Listing

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