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Parental and Medical Classification of Neurodevelopment in Children Born Preterm.
Pediatrics
January 2025
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Background And Objectives: The likelihood and severity of neurodevelopmental impairment (NDI) affects critical health care decisions. NDI definitions were developed without parental perspectives. We investigated the agreement between parental vs medical classification of NDI among children born preterm.
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Alzheimers Dement
December 2024
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Background: Finding low-cost, accessible methods to detect people with early-stage Alzheimer's disease is a research priority for neuroprotective drug development. Subtle motor impairment of gait occurs years before episodic memory decline but there has been little investigation of whether self-administered hand motor tests can detect this pre-symptomatic period. This study evaluated how home-based unsupervised keyboard tapping tests from the TAS Test protocol predict episodic memory performance in a sample of older adults without overt cognitive impairment, as a potential indicative measure of early Alzheimer's disease.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is multifactorial, thus multivariate analyses help untangle its effects. We employed multiple contrast MRI to reveal age-related brain changes in populations at risk for AD, due to APOE4 carriage. We assessed volume and microstructure changes using diffusion weighted imaging, and quantitative magnetic susceptibility maps (QSM) reflective primarily of cerebral iron metabolism.
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Alzheimers Dement
December 2024
Department of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, New York, NY, USA.
Background: Motoric Cognitive Risk (MCR) syndrome is a predementia syndrome characterized by slow gait and subjective cognitive concerns. Individuals with MCR are at high risk of transitioning to both Alzheimer's disease (AD) and vascular dementia. With chronological age, the incidence of MCR increases and MCR cases exhibit a higher prevalence of age-associated diseases.
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Alzheimers Dement
December 2024
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Background: The process for assessing cognitive symptoms in clinic is time consuming, expensive and usually requires multiple clinicians. There is an urgent need for accessible, quick and low-cost methods to aid identification of people at the early stages of the dementia continuum. Emerging evidence shows that simple hand movement tests could aid risk stratification.
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