Reductive amination catalyzed by iridium complexes using carbon monoxide as a reducing agent.

Org Biomol Chem

A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, 119991, Vavilova St. 28, Moscow, Russian Federation. and Faculty of Science, RUDN University, 6 Miklukho-Maklaya St., Moscow 117198, Russian Federation.

Published: August 2017

Development of novel, sustainable catalytic methodologies to provide access to amines represents a goal of fundamental importance. Herein we describe a systematic study for the construction of a variety of amines catalyzed by a well-defined homogeneous iridium complex using carbon monoxide as a reducing agent. The methodology was shown to be compatible with functional groups prone to reduction by hydrogen or complex hydrides.

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http://dx.doi.org/10.1039/c7ob01005bDOI Listing

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