Mild traumatic brain injury (mTBI) is increasingly recognized as a significant public health problem which warrants additional research. Part of the effort to understand mTBI and concussion includes modeling in animals. Controlled cortical impact (CCI) is a commonly employed and well-characterized model of experimental TBI that has been utilized for three decades. Today, several commercially available pneumatic- and electromagnetic-CCI devices exist as do a variety of standard and custom injury induction tips. One of CCI's strengths is that it can be scaled to a number of common laboratory animals. Similarly, the CCI model can be used to produce graded TBI ranging from mild to severe. At the mild end of the injury spectrum, CCI has been applied in many ways, including to study open and closed head mTBI, repeated injuries, and the long-term deficits associated with mTBI and concussion. The purpose of this mini-review is to introduce the CCI model, discuss ways the model can be applied to study mTBI and concussion, and compare CCI to alternative pre-clinical TBI models.
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| http://dx.doi.org/10.3390/brainsci7070088 | DOI Listing |
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Gait during community ambulation and laboratory-based walking in people with mild traumatic brain injury.
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Department of Neurology, Oregon Health & Science University, Portland, OR, United States. Electronic address:
Background: Gait impairments are common in individuals with mild traumatic brain injury (mTBI), presenting in the acute phase and often persisting in subtle ways over time. Despite the prominence of laboratory gait evaluations, a comprehensive understanding of gait deficits post-mTBI necessitates the examination of various gait domains in real-world environments. Assessing gait during a community ambulation task (CAT) may capture real-world challenges and influence focused interventions or rehabilitation in individuals with mTBI.
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J Head Trauma Rehabil
September 2024
Author Affiliations: Department of Psychology, University of Calgary, Calgary, Alberta (Ms Luszawski and Dr Yeates); Alberta Children's Hospital Research Institute, Calgary, Alberta (Ms Luszawski and Dr Yeates); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta (Ms Luszawski and Dr Yeates); Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio (Ms Minich, Dr Bacevice, and Dr Bangert); Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio (Ms Minich and Dr Bacevice); Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah and Departments of Neurology and Psychiatry, University of Utah, Salt Lake City, Utah (Dr Bigler); Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio (Dr Taylor); Department of Pediatrics, The Ohio State University, Columbus, Ohio (Drs Taylor, Cohen, and Zumberge); Emergency Medicine, Nationwide Children's Hospital, Columbus, Ohio (Dr Cohen); Department of Radiology, University Hospitals of Cleveland, Cleveland, Ohio (Dr Bangert); Radiology, Nationwide Children's Hospital, Columbus, Ohio (Dr Zumberge); Educational and Counselling Psychology, University of British Columbia, Vancouver, British Columbia (Dr Tomfohr-Madsen); Neurosciences Program, Alberta Children's Hospital, Calgary, Alberta (Dr Brooks); and Departments of Pediatrics, Clinical Neurosciences, and Psychology, University of Calgary, Calgary, Alberta (Dr Brooks).
Objective: Sleep disturbance (SD) is common after pediatric mild traumatic brain injury (mTBI) and may predict increased postconcussive symptoms (PCS) and prolonged recovery. Our objective was to investigate the relation of SD with PCS in children with mTBI and those with orthopedic injury (OI).
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Department of Neurology, Haaglanden Medical Center, PO Box 432, 2501 CK, The Hague, The Netherlands.
Background And Importance: Traumatic intracranial hemorrhage (tICH) after mild traumatic brain injury (mTBI) is not uncommon in the elderly. Often, these patients are admitted to the hospital for observation. The necessity of admission in the absence of clinically important intracranial injuries is however unclear.
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Evaluating a 12-week aerobic exercise intervention in adults with persisting post-concussive symptoms.
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Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Calgary, Calgary, AB, Canada.
Background: Although guidelines support aerobic exercise in sub-acute mild traumatic brain injury (mTBI), evidence for adults with persisting post-concussive symptoms (PPCS) after mTBI is lacking. The objective was to evaluate the impact of a sub-symptom threshold aerobic exercise intervention on overall symptom burden and quality of life in adults with PPCS.
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