AI Article Synopsis
- The study discusses the recovery of Escherichia coli Ec36 from a Portuguese patient who had been treated with meropenem and colistin.
- E. coli Ec36 carries an IncF plasmid with a Tn1441d-bla gene, which is previously documented in clinical strains in Portugal, indicating a known resistance mechanism.
- Additionally, this strain has an IncX4::mcr-1 gene, revealing new co-resistance to both carbapenems and polymyxins, raising concerns about treatment efficacy.
Article Abstract
Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-bla, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547783 | PMC |
| http://dx.doi.org/10.3201/eid2308.170162 | DOI Listing |
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