AI Article Synopsis
- - After a major infection or trauma, the body's ability to fight off new infections can weaken, a condition referred to as sepsis-induced immunosuppression.
- - Research highlighted in Immunity by Roquilly et al. (2017) reveals that certain immune cells, like dendritic cells and macrophages, change their characteristics in the lungs post-infection.
- - These immune cells adopt tolerogenic properties that lead to long-lasting immunosuppression, making individuals more prone to secondary infections.
Article Abstract
Following a severe primary infection or trauma, the risk of developing pneumonia increases due to acquired immune defects collectively known as sepsis-induced immunosuppression. In this issue of Immunity, Roquilly et al. (2017) show that dendritic cells and macrophages developing in the lung after the resolution of a severe infection acquire tolerogenic properties that contribute to persistent immunosuppression and susceptibility to secondary infections.
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| http://dx.doi.org/10.1016/j.immuni.2017.07.007 | DOI Listing |
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