AI Article Synopsis
- The communication discusses the creation of a functional polymer that includes an indole group, using a specific method called RAFT (reversible-addition fragmentation and chain transfer).
- It further describes modifying this polymer with a 'click' reaction involving a chemical compound known as TAD.
- The final polymer exhibited properties such as the ability to reverse its shape with heat and the capacity to heal itself when damaged.
Article Abstract
This communication reports the preparation and characterization of a functional polymer bearing a pendant indole group via a reversible-addition fragmentation and chain transfer (RAFT) process followed by its modification via an Alder-ene 'click' reaction using a 1,2,4-triazoline-3,5-dione (TAD) derivative. The resultant functional polymer showed thermo-reversible as well as healing characteristics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c7cc02980b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering Acid-Promoted Two-Photon Ratiometric Nanoprobes for Evaluating HClO in Lysosomes and Inflammatory Bowel Disease.
ACS Appl Mater Interfaces
January 2025
Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, Laboratory of Functionalized Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.
HClO is considered a potential contributing factor and biomarker of inflammatory bowel disease (IBD). Accurate monitoring of lysosomal HClO is important for further developing specific diagnostic and therapeutic schedules for IBD. However, only rare types of fluorescent probes have been reported for detecting HClO in IBD so far.
View Article and Find Full Text PDFCascade-Responsive Nanoparticles for Efficient CRISPR/Cas9-Based Glioblastoma Gene Therapy.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China.
CRISPR/Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing technology represents great promise for treating glioblastoma (GBM) due to its potential to permanently eliminate tumor pathogenic genes. Unfortunately, delivering CRISPR to the GBM in a safe and effective manner is challenging. Herein, a glycosylated and cascade-responsive nanoparticle (GCNP) that can effectively cross the blood-brain barrier (BBB) and activate CRISPR/Cas9-based gene editing only in the GBM is designed.
View Article and Find Full Text PDFSelf-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis.
Adv Mater
January 2025
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.
Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application to tumors. To overcome these limitations, a self-sustained organelle-mimicking nanoreactor is developed here with programmable DNA switches that enables bio-chem-photocatalytic cascade-driven starvation-photodynamic synergistic therapy against tumor metastasis. Emulating the compartmentalization and positional assembly strategies found in living cells, this nano-organelle reactor allows quantitative co-compartmentalization of multiple functional modules for the designed self-illuminating chemiexcited PDT system.
View Article and Find Full Text PDFAssessing Caries Removal Efficacy and Pain Perception in Children, Using Smart Bur Versus Carbide Bur: A Randomized Clinical Study.
Med Sci Monit
January 2025
Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
BACKGROUND Dental caries removal is conventionally done using carbide burs, but non-metallic polymer burs have recently been developed with the aim of being more selective and causing less pain. The objective of the study is to evaluate and compare the effectiveness of caries removal, time taken, and patient compliance during restorations using smart bur and carbide burs in pediatric patients. MATERIAL AND METHODS A clinical study was designed and conducted at the Pedodontics Outpatient Department, with a focus on 40 children between 6 and 12 years old, who were split into 2 groups consisting of 20 children each: group 1, using a carbide conventional rotary bur, and group 2, using a smart bur.
View Article and Find Full Text PDFLuminescence Lifetime-Based Water Conductivity Sensing Using a Cationic Dextran-Supported Ru(II) Polypyridyl Complex.
Sensors (Basel)
December 2024
Chemical Optosensors & Applied Photochemistry Group (GSOLFA), Department of Organic Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain.
Water conductivity sensing relies universally on electrical measurements, which are subject to corrosion of the electrodes and subsequent signal drift in prolonged in situ uses. Furthermore, they cannot provide contactless sensing or remote readout. To this end, a novel device for water conductivity monitoring has been developed by employing a microenvironment-sensitive ruthenium complex, [Ru(2,2'-bipyridine-4,4'-disulfonato)], embedded into a quaternary ammonium functionalized cross-linked polymer support.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!