Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.
Methods: We genotyped , , and in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone C-labeled Pittsburgh compound B-positron emission tomography imaging.
Results: Patients with EOAD exhibited higher scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (<0.05, false discovery rate).
Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500536 | PMC |
http://dx.doi.org/10.2147/CIA.S132884 | DOI Listing |
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