"Prenervous" neurotransmitters interact with second messengers in the regulation of early embryogenesis of sea urchins and the clawed frog Xenopus laevis. Propranolol and atropine inhibit cleavage divisions of X. laevis only after their intracellular administration. The level of the membrane potential (including a zero level) of the embryos studied is not essential for the cleavage divisions. Possible mechanisms of action of the "prenervous" neurotransmitters at the intracellular level and their coupling with second messengers are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0742-8413(86)90147-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identifying Allosteric Hotspots in cAMP Receptor Protein through Structural Homology.
Biochemistry
January 2025
Department of Chemistry, Georgetown University, Washington, District of Columbia 20057, United States.
Understanding the mechanisms of allosteric regulation in response to second messengers is crucial for advancing basic and applied research. This study focuses on the differential allosteric regulation by the ubiquitous signaling molecule, cAMP, in the cAMP receptor protein from (CRP) and from (CRP). By introducing structurally homologous mutations from allosteric hotspots previously identified in CRP into CRP and examining their effects on protein solution structure, stability and function, we aimed to determine the factors contributing to their differential allosteric regulation.
View Article and Find Full Text PDFTranscellular regulation of ETI-induced cell death.
Trends Plant Sci
January 2025
State Key Laboratory of Wheat Improvement, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; Shandong Engineering Research Center of Plant-Microbial Restoration for Saline-Alkali Land, Shandong Agricultural University, Tai'an, 271018, China. Electronic address:
To address the persistent challenge of cell death spread and limitation during effector-triggered immunity (ETI), we propose a 'concentric circle' model. This model outlines a regulatory framework, integrating multiple cells and diverse signaling molecules, including salicylic acid (SA), jasmonic acid (JA), and Ca. By accounting for the varying concentrations and spatiotemporal distributions of these molecules, our model aims for precision in immune defense and regulated cell death.
View Article and Find Full Text PDFThe Role of CBGTC Synaptic Neurotransmission in the Pathophysiology of Tics.
Psychiatr Clin North Am
March 2025
Department of Neurology, Johns Hopkins University School of Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.
The pathophysiology of tic disorders involves an alteration in the transmission of messages through the cortico-basal ganglia-thalamo-cortical circuit. A major requirement for the passage of a message through this circuit is an intact chemically mediated synaptic neurotransmitter system (ie, neurotransmitters and second messengers). This article reviews the scientific evidence supporting the involvement of a variety of neurotransmitters (ie, dopamine, glutamate, gamma-aminobutyric acid, serotonin, acetylcholine, and the opioid system).
View Article and Find Full Text PDFExpression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa.
Physiol Rep
February 2025
Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center of Functional Genomics, Berlin, Germany.
The zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation.
View Article and Find Full Text PDFCAMK2D and Complement Factor I-Involved Calcium/Calmodulin Signaling Modulates Sodium Iodate-Induced Mouse Retinal Degeneration.
Invest Ophthalmol Vis Sci
January 2025
School of Graduate, Dalian Medical University, Dalian City, China.
Purpose: To investigate the effect of Ca2+/calmodulin-dependent protein kinase II (CAMKII) δ subtypes (CAMK2D) on sodium iodate (NaIO3)-induced retinal degeneration in mice.
Methods: Bioinformatics analysis and Western blot experiments were used to screen the significantly differentially expressed genes in age-related macular degeneration (AMD) disease. CAMK2D knockdown and overexpression models were constructed by lentivirus (LV) infection of adult retinal pigment epithelial cell line-19 (ARPE-19) cells in vitro.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!