AI Article Synopsis
- Metabolic disorders contribute to over 60% of global deaths, with vitamin D (calcitriol) deficiency linked to many of these conditions, making it a key focus for treatment research.
- This study assessed the effects of high doses of vitamin D (3000 IU/kg) on obese, insulin-resistant mice, finding improvements in insulin sensitivity and reductions in body weight.
- However, there were adverse effects, specifically significant kidney damage in the treated mice, indicating the need for careful dosing and further investigation into the renal impact.
Article Abstract
Preclinical Research Metabolic disorders are responsible for more than 60% of all deaths worldwide. Calcitriol or vitamin D (vitD) deficiency is associated with a large proportion of these diseases is an important therapeutic target for exploration. This study evaluated the administration of high doses of vitD (3000 IU/kg) in obese and insulin-resistant C57BL/6J mice. Our results demonstrated that although high doses of vitD provided metabolic benefits such as increased insulin sensitivity and decreased body mass, this was associated with significant damage in the kidneys of obese mice. These findings support the role of vitD as a therapeutic strategy against metabolic disorders. However, caution is required with the dose administrated, and the renal damage associated still needs to be investigated. Drug Dev Res 78 : 203-209, 2017. © 2017 Wiley Periodicals, Inc.
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| http://dx.doi.org/10.1002/ddr.21394 | DOI Listing |
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