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Activation and synchronization of the oscillatory morphodynamics in multicellular monolayer. | LitMetric

Activation and synchronization of the oscillatory morphodynamics in multicellular monolayer.

Proc Natl Acad Sci U S A

Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China;

Published: August 2017

AI Article Synopsis

  • - Oscillatory morphodynamics are crucial for multicellular processes, requiring coordinated cell dynamics, even when cells are too far apart to communicate directly through materials.
  • - This study focuses on the amnioserosa tissue to understand how mechanical components influence collective oscillations, particularly through the role of tensile stress in activating or deactivating these oscillations.
  • - Using Hopf bifurcation theory, the research shows that the physical properties of the tissue boundary help synchronize oscillation intensity and direction among inner cells, shaping overall spatial patterns in the tissue.

Article Abstract

Oscillatory morphodynamics provides necessary mechanical cues for many multicellular processes. Owing to their collective nature, these processes require robustly coordinated dynamics of individual cells, which are often separated too distantly to communicate with each other through biomaterial transportation. Although it is known that the mechanical balance generally plays a significant role in the systems' morphologies, it remains elusive whether and how the mechanical components may contribute to the systems' collective morphodynamics. Here, we study the collective oscillations in the amnioserosa tissue to elucidate the regulatory roles of the mechanical components. We identify that the tensile stress is the key activator that switches the collective oscillations on and off. This regulatory role is shown analytically using the Hopf bifurcation theory. We find that the physical properties of the tissue boundary are directly responsible for synchronizing the oscillatory intensity and polarity of all inner cells and for orchestrating the spatial oscillation patterns inthe tissue.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547635PMC
http://dx.doi.org/10.1073/pnas.1705492114DOI Listing

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