Targeting the epigenome in malignant pleural mesothelioma.

Transl Lung Cancer Res

Thoracic Epigenetics Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Published: June 2017

Malignant pleural mesotheliomas (MPM) are notoriously refractory to conventional treatment modalities. Recent insights regarding epigenetic alterations in MPM provide the preclinical rationale for the evaluation of novel combinatorial regimens targeting the epigenome in these neoplasms.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504118PMC
http://dx.doi.org/10.21037/tlcr.2017.06.06DOI Listing

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