AI Article Synopsis
- Seven calcium oxalate stone-formers and ten healthy individuals were studied to understand how urine affects the crystallization of calcium oxalate monohydrate, focusing on solubility, crystal growth, and agglomeration.
- Urine from stone-formers had low solubility for calcium oxalate and normal inhibition of crystal growth but failed to prevent crystal agglomeration.
- Restoring urinary citrate levels significantly enhanced the ability to inhibit agglomeration, highlighting the importance of citrate in calcium oxalate stone formation.
Article Abstract
In 7 highly recurrent calcium oxalate stone-formers and 10 healthy subjects the effects of urine on three processes of calcium oxalate monohydrate crystallisation--solubility, crystal growth, and crystal agglomeration--were studied. The urine of the stone-formers showed low calcium oxalate solubility and normal crystal growth inhibition, but lacked the ability to inhibit crystal agglomeration. As the sole metabolic abnormality, all stone-formers showed hypocitraturia. Normalisation of urinary citrate concentration resulted both in vitro and in vivo in a significant rise in agglomeration inhibition. These results show that inhibition of agglomeration is a very important, probably citrate-regulated, process in calcium oxalate stone formation.
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| http://dx.doi.org/10.1016/s0140-6736(86)91329-2 | DOI Listing |
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