Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595643 | PMC |
| http://dx.doi.org/10.1016/j.bbalip.2017.07.003 | DOI Listing |
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