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Prognostic F-flotufolastat PET parameters for outcome assessment of Lu-labeled PSMA-targeted radioligand therapy in metastatic castration-resistant prostate cancer.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Purpose: This retrospective analysis evaluates baseline F-flotufolastat positron emission tomography (PET) parameters as prognostic parameters for treatment response and outcome in patients with metastatic castration-resistant prostate cancer (mCRPC) undergoing treatment with [Lu]Lu-PSMA-I&T.
Methods: A total of 188 mCRPC patients with baseline F-flotufolastat PET scans were included. Tumor lesions were semiautomatically delineated, with imaging parameters including volume-based and standardized uptake value (SUV)-based metrics.
Early handwriting development: a longitudinal perspective on handwriting time, legibility, and spelling.
Front Psychol
January 2025
Institute of Special Needs Education, Bern University of Teacher Education, Bern, Switzerland.
Introduction: Learning to write is a complex task involving peripheral (e.g., handwriting speed and legibility) and central (e.
View Article and Find Full Text PDFEstimating mortality attributable to alcohol or tobacco - a cohort study from Germany.
Subst Abuse Treat Prev Policy
January 2025
Dep Prevention Research and Social Medicine, University Medicine Greifswald, Institute of Community Medicine, W.-Rathenau-Str. 48, 17475, Greifswald, Germany.
Background: Little is known about mortality from four disorder combinations: fully attributable to alcohol or tobacco, partly attributable to both alcohol and tobacco, to tobacco only, to alcohol only.
Aim: To analyze whether residents who had disclosed risky alcohol drinking or daily tobacco smoking had a shorter time to death than non-risky drinkers and never daily smokers twenty years later according to the disorder combinations.
Methods: A random adult general population sample (4,075 study participants) of a northern German area had been interviewed in the years 1996-1997.
Gamma and theta/alpha-band oscillations in the electroencephalogram distinguish the content of inner speech.
eNeuro
January 2025
Research School of Psychology, Australian National University, 0200, Australia.
Inner speech refers to the silent production of language in one's mind. As a purely mental action without obvious physical manifestations, inner speech has been notoriously difficult to quantify. Inner speech is thought to be closely related to overt speech.
View Article and Find Full Text PDFSpeak and you shall predict: evidence that speech at initial cocaine abstinence is a biomarker of long-term drug use behavior.
Biol Psychiatry
January 2025
Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029; Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029. Electronic address:
Background: Valid scalable biomarkers for predicting longitudinal clinical outcomes in psychiatric research are crucial for optimizing intervention and prevention efforts. Here we recorded spontaneous speech from initially abstinent individuals with cocaine use disorder (iCUD) for use in predicting drug use outcomes.
Methods: At baseline, 88 iCUD provided 5-minute speech samples describing the positive consequences of quitting drug use and negative consequences of using drugs.
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