A mild and metal-free regiodivergent addition of carbon nucleophiles to α,β-unsaturated electrophiles was developed. Total 1,2-regioselectivity was observed in the addition of nitrobenzyl chloride derivative to α,β-unsaturated aldehydes in the presence of TDAE. Moreover, the reaction between -nitrobenzyl chloride and α,β-unsaturated iminium salts led to the formation of the 1,4-adduct with total regioselectivity.
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| http://dx.doi.org/10.3390/molecules22071178 | DOI Listing |
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