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Comparison of the Abbott Alinity m and Qiagen Artus assays for the quantification of BK virus in clinical samples.
IJID Reg
March 2025
Virology Department, Hôpital Paul Brousse, INSERM U1193, AP-HP, Université Paris Saclay, Paris, France.
Objectives: BK virus (BKV) is highly seroprevalent in humans. After primary infection, it remains latent in the urinary tract and can reactivate in immunocompromised individuals, leading to interstitial nephropathy or hemorrhagic cystitis. The BKV viral load (VL) in plasma correlates with the occurrence of nephropathy and can be monitored in kidney graft recipients; the early detection of BKV viremia can enable an early reduction of immunosuppressant drug doses and the prevention of BKV-associated nephropathy.
View Article and Find Full Text PDFVolume kinetic analysis of 2 crystalloid fluid bolus rates in anesthetized cats.
J Vet Emerg Crit Care (San Antonio)
January 2025
J. T. Vaughan Large Animal Teaching Hospital, Auburn University, Auburn, Alabama, USA.
Objective: To investigate the volume kinetic between 2 crystalloid fluid bolus rates in anesthetized cats.
Design: Prospective, randomized, dose-response study.
Setting: University laboratory.
Phenol Dilution With Saline Solution Versus Alcohol in Partial Matricectomy for Onychocryptosis.
Dermatol Surg
January 2025
Department of Dermatology, Valencian Community, Hospital San Juan, Alicante, Spain.
Background: Onychocryptosis significantly impacts quality of life. Chemical partial matricectomy with phenol is a common surgical treatment. The use of alcohol as a solvent during this procedure has been controversial.
View Article and Find Full Text PDFNeurofilament Light Chain under the Lens of Structural Mass Spectrometry.
ACS Chem Neurosci
January 2025
National Measurement Laboratory, LGC, Queens Road, TW11 0LY Teddington, U.K.
Neurofilament light chain (NfL) is an early nonspecific biomarker in neurodegenerative diseases and traumatic brain injury, indicating axonal damage. This work describes the detailed structural characterization of a selected primary calibrator with the potential to be used in future reference measurement procedure (RMP) development for the accurate quantification of NfL. As a part of the described workflow, the sequence, higher-order structure as well as solvent accessibility, and hydrogen-bonding profile were assessed under three different conditions in KPBS, artificial cerebrospinal fluid, and artificial cerebrospinal fluid in the presence of human serum albumin.
View Article and Find Full Text PDFComparative study of labour analgesia onset with injection of loading dose through epidural needle versus catheter: A prospective, double-blinded, randomised clinical trial.
Eur J Anaesthesiol
February 2025
From the Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China (XC, YT, QY, LS, HL, LW, CJ, XC).
Background: Rapid onset of epidural analgesia is an important concern for the parturient. Commonly, the local anaesthetic mixture is administered through the epidural catheter. Drugs administered through the epidural needle might decrease the onset time and enhance the spread of medication within the epidural space.
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