Objective: Assess the role of inflammation on operating time in younger vs. older bariatric surgery patients.
Methods: Fifty-five younger (F: 46, Age: 34.9 ± 4.0 years, body mass index [BMI]: 48.2 ± 1.0 kg m) and 48 older (F: 34, Age: 57.0 ± 5.1 years, BMI: 46.8 ± 1.0 kg m) adults were studied prior to surgery. Blood pressure, glycaemic control (fasting glucose/insulin, HbA), lipids (high-density lipoprotein and triglycerides) and inflammation (monocyte chemoattractant protein-1 [MCP-1]) were assessed. Metabolic risk severity -scores were calculated from clinical outcomes. Omental adipose biopsies were collected at surgery for MCP-1 protein analysis. Operating time was used to characterize surgical difficulty.
Results: Older vs. younger adults had higher HbA ( = 0.03). There was no difference in BMI, lipids, metabolic risk severity or insulin between groups, but operating time was longer in older vs. younger individuals ( = 0.04). Circulating MCP-1 was also elevated in older vs. younger adults ( = 0.04) independent of HbA, although this was not explained by omental fat. Nevertheless, serum MCP-1 was associated with increased metabolic risk severity ( = 0.27, = 0.01). In addition, operating time was linked to HbA ( = 0.30, = 0.01) and omental MCP-1 protein ( = 0.31, < 0.01).
Conclusions: MCP-1 is associated with longer operating time and increased metabolic risk severity in older bariatric patients independent of glycaemic control. Pre-operative treatment of inflammation may be required to enhance surgery effectiveness.
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| http://dx.doi.org/10.1002/osp4.105 | DOI Listing |
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