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Limb salvage surgery has become the primary means of treatment for patients with malignant tumors of the extremities and pelvis. For these patients, endoprostheses have become the principal means to reconstruct the extremity following an oncologic resection because they offer an off-the-shelf-option that is modular, cost effective, and durable. As with other forms of arthroplasty, several modes of failure can occur, with infection being common.
View Article and Find Full Text PDFDelivery determinants of an type VI secretion system bifunctional peptidoglycan hydrolase.
mBio
December 2024
Infection Program, Department of Microbiology, Monash University, Biomedicine Discovery Institute, Melbourne, Victoria, Australia.
is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The clinical isolate AB307-0294 produces a type VI secretion system (T6SS) that delivers three antibacterial effector proteins that give this strain a competitive advantage against other bacteria in polymicrobial environments.
View Article and Find Full Text PDFAn Ultramicroporous Physisorbent Sustained by a Trifecta of Directional Supramolecular Interactions.
J Am Chem Soc
January 2025
Bernal Institute and Department of Chemical Sciences, University of Limerick, Limerick V94 T9PX, Ireland.
2D and 3D porous coordination networks (PCNs) as exemplified by metal-organic frameworks, MOFs, have garnered interest for their potential utility as sorbents for molecular separations and storage. The inherent modularity of PCNs has enabled the development of crystal engineering strategies for systematic fine-tuning of pore size and chemistry in families of related PCNs. The same cannot be said about one-dimensional (1D) coordination polymers, CPs, which are understudied with respect to porosity.
View Article and Find Full Text PDFResearch and application of intelligent diagnosis and treatment engineering bacteria.
Front Bioeng Biotechnol
December 2024
Department of Gynecology, Peking University First Hospital Ningxia Women and Children's Hospital, Yinchuan, Ningxia, China.
For over a century, scientists have been harnessing the therapeutic potential of bacteria in treating diseases. The advent of synthetic biology in recent years has propelled the development of genetically engineered bacteria with enhanced intelligence. These bacteria can autonomously detect environmental cues and relay them to pivotal promoters, leading to the expression of functional proteins.
View Article and Find Full Text PDFDesign and Evaluation of 3D-Printed Lattice Structures as High Flow Rate Aerosol Filters.
ACS Appl Eng Mater
December 2024
Department of Chemical and Biomolecular Engineering and Department of Biomedical Engineering, University of Delaware, 150 Academy Street, Newark, Delaware 19716, United States.
Aerosol contamination presents significant challenges across various industries, ranging from healthcare to manufacturing. Over the past few years, open foam filters have gained prominence for their ability to efficiently capture particles while allowing reasonable airflow. In this work, we present the use of 3D-printed idealized open foam-like lattice structures as aerosol filtration media, leveraging advances in additive manufacturing to generate these highly tunable and modular filters.
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