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The ZnGaCrO persistent luminescence nanoparticles offer the promise of revolutionary tools for biological imaging with applications such as cell tracking or tumor detection. They can be re-excited through living tissues by visible photons, allowing observations without any time constraints and avoiding the undesirable auto-fluorescence signals observed when fluorescent probes are used. Despite all these advantages, their uses demand extensive toxicological evaluation and control. With this purpose, mice were injected with a single intravenous administration of hydroxylated or PEGylated persistent luminescence nanoparticles at different concentrations and then a set of standard tests were carried out 1day, 1 month and 6 months after the administration. High concentrations of hydroxylated nanoparticles generate structural alterations at histology level, endoplasmic reticulum damage and oxidative stress in liver, as well as rising in white blood cells counts. A mechanism involving the endoplasmic reticulum damage could be the responsible of the observed injuries in case of ZGO-OH. On the contrary, no toxicological effects related to PEGylated nanoprobes treatment were noted during our in vivo experiments, denoting the protective effect of PEG-functionalization and thereby, their potential as biocompatible in vivo diagnostic probes.
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http://dx.doi.org/10.1016/j.ijpharm.2017.07.015 | DOI Listing |
Adv Mater
December 2024
College of Chemistry and Molecular Sciences, Renmin Hospital of Wuhan University, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan, 430072, P. R. China.
Inspired by the natural responsive phenomena, herein the multiple responsive persistent luminescent ZnGaGeO:Ni (ZGGO:Ni) nanoparticles with near-infrared (NIR) II emission peak ≈1330 nm derived from the Ni doping through controlled synthesis based on hydrothermal method are obtained. The obtained NIR II persistent luminescent ZGGO:Ni can not only respond to temperature but also the specific solvent stimulus. The results demonstrate that the NIR II persistent luminescence intensity decreases in hydroxyl containing solvent such as water (HO) and ethyl alcohol (CHO), while the PL intensity remains in solvent without hydroxyl groups such as n-hexane (CH) and deuterated water (DO).
View Article and Find Full Text PDFInorg Chem
December 2024
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, Frontiers Science Center for Rare Isotope, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Metal-organic hybrid materials with long persistent luminescence (LPL) properties have attracted a lot of attention due to their enormous potential for applications in information encryption, anticounterfeiting, and other correlation fields. However, achieving multimodal luminescence in a single component remains a significant challenge. Herein, we report two two-dimensional LPL coordination polymers: {[Zn(BA)(BIMB)]·2HO} () and {[Cd(BA)(BIMB)]·3HO} () (BIMB = 1,3-bis(imidazol-1-yl)benzene; BA = butanedioic acid).
View Article and Find Full Text PDFAdv Mater
December 2024
Key Laboratory of Weak-Light Nonlinear Photonics, Ministry of Education, School of Physics, Nankai University, Tianjin, 300071, China.
With the development of optical anti-counterfeiting and the increasing demand for high-level information encryption, multimodal luminescence (MML) materials attract much attention. However, the discovery of these multifunctional materials is very accidental, and the versatile host suitable for developing such materials remains unclear. Here, a grossite-type fast ionic conductor CaGaO, characterized by layered and tunnel structure with excellent defect tolerance, is found to meet the needs of various luminescent processes.
View Article and Find Full Text PDFInorg Chem
December 2024
School of Physics and Optoelectronic Technology, Collaborative Innovation Center of Rare-Earth Optical Functional Materials and Devices Development, Baoji University of Arts and Sciences, Baoji, Shaanxi 721016, China.
Mechanoluminescent (ML) materials have shown promising applications in visualized mechanical sensing, imaging, and real-time monitoring because of their unique mechanics-optics conversion. However, the short emission lifetime of transient ML presents challenges in overcoming temporal and spatial constraints in practical applications. In this work, a mechanically charged persistent ML material was created by compositing the CaNaMg(PO):Tb and flexible poly(dimethylsiloxane) (PDMS) matrix.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Amino acid-based biomolecular glasses represent an emerging material to meet the demand for sustainable development. However, most amino acids are difficult to vitrify due to their strong crystallization tendency, limiting further advancements of this field. In this study, we demonstrate that the introduction of counterions effectively suppresses crystallization, as hydrogen bonds within the system stabilize the disordered structures.
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