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Caryophyllane Thiols, Vinyl Thioethers, Di- and Bis-Sulfides: Antioxidant and Membrane Protective Activities. | LitMetric
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Caryophyllane Thiols, Vinyl Thioethers, Di- and Bis-Sulfides: Antioxidant and Membrane Protective Activities.

Yulia V Gyrdymova Denis V Sudarikov Oksana G Shevchenko Svetlana A Rubtsova Pavel A Slepukhin Aleksandr V Kutchin

Chem Biodivers

Institute of Chemistry of the Komi Science Center, Ural Branch of the Russian Academy of Sciences, 48, Pervomaiskaya Ul., Syktyvkar, 167000, Russia.

Published: December 2017

Caryophyllane thioterpenoids were synthesized in 23 - 81% yields. The antioxidant properties of the obtained compounds in various model systems were found. It was revealed that 4,5-epoxycaryophyll-9-ylmethanethiol has the greatest antioxidant activity. The isomerism of sesquiterpenic fragments was shown to have a significant effect on the biological activity of the compounds.

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http://dx.doi.org/10.1002/cbdv.201700296DOI Listing

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