Zinc absorption in animals is thought to be regulated in a local, cell autonomous manner with intestinal cells responding to dietary zinc content. The Drosophila zinc transporter Zip88E shows strong sequence similarity to Zips 42C.1, 42C.2 and 89B as well as mammalian Zips 1, 2 and 3, suggesting that it may act in concert with the apically-localised Drosophila zinc uptake transporters to facilitate dietary zinc absorption by importing ions into the midgut enterocytes. However, the functional characterisation of Zip88E presented here indicates that Zip88E may instead play a role in detecting and responding to zinc toxicity. Larvae homozygous for a null Zip88E allele are viable yet display heightened sensitivity to elevated levels of dietary zinc. This decreased zinc tolerance is accompanied by an overall decrease in Metallothionein B transcription throughout the larval midgut. A Zip88E reporter gene is expressed only in the salivary glands, a handful of enteroendocrine cells at the boundary between the anterior and middle midgut regions, and in two parallel strips of sensory cell projections connecting to the larval ventral ganglion. Zip88E expression solely in this restricted subset of cells is sufficient to rescue the Zip88E mutant phenotype. Together, our data suggest that Zip88E may be functioning in a small subset of cells to detect excessive zinc levels and induce a systemic response to reduce dietary zinc absorption and hence protect against toxicity.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181237 | PLOS |
Andes Pediatr
October 2024
Facultad de Medicina, Departamento de Gastroenterología y Nutrición Pediátrica, Pontificia Universidad Católica de Chile, Santiago, Chile.
Unlabelled: The Ketogenic Diet (KD) is a non-pharmacological strategy for drug-resistant epilepsy (DRE) and inborn errors of metabolism (Glut-1 deficiency) management. KD is characterized by being restrictive, affecting micronutrient intake. There are different modalities of KD in which food intake and nutritional deficiencies vary.
View Article and Find Full Text PDFJ Pediatr Endocrinol Metab
January 2025
Department of Pediatrics, Konya City Hospital, University of Health Sciences, Konya, Türkiye.
Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.
Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.
Aquac Nutr
December 2024
Norwegian Institute of Food, Fisheries and Aquaculture Research (Nofima), Bergen, Norway.
Two short-term feeding trials were conducted on , with the interaction between dietary zinc (Zn) and fat level in trial 1 and with the interaction between dietary Zn and n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) in trial 2, focusing on postprandial plasma parameters, intestinal Zn and fat uptake and transport. After 4-week feeding interventions, samples were collected at different postprandial time points, ranging from 0 to 36/38 h after feeding. Results showed that increased Zn level in feed significantly increased the postprandial plasma Zn level in trial 1 (8-9°C).
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Urology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Background: Urinary incontinence (UI), particularly urge urinary incontinence (UUI), is a prevalent condition that worsens with age and negatively affects quality of life. Antioxidants, measured by the composite dietary antioxidant index (CDAI), have been linked to inflammation and other diseases, but their relationship with UUI remains uncertain. The purpose of this study is to investigate the relationship between UUI prevalence and CDAI.
View Article and Find Full Text PDFJ Clin Aesthet Dermatol
December 2024
Dr. Barbosa Bueno de Campos is with Allergisa in Campinas, Brazil.
Objective: The desire for improved hair appearance, hair growth and strength are common drivers of supplementation for women experiencing thinning hair. This study examined the effect and safety of a gummy supplement containing B vitamins, zinc and botanical ingredients to improve hair growth, strength and perceived hair quality outcomes.
Methods: Healthy females (n=65) ages 18 to 60 with thinning hair were enrolled.
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