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Assessment of the Accuracy of Ultrasonographically Measured Optic Nerve Sheath Diameter as a Surrogate for the Detection of Intracranial Hypertension Compared to Optic Nerve Sheath Diameter Measured by MRI: A Prospective Observational Study.
Cureus
December 2024
Anaesthesiology and Critical Care, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Background: Ultrasonographic measurement of optic nerve sheath diameter (ONSD) has been proposed as a non-invasive, bedside method to detect raised intracranial pressure (ICP) in various clinical settings. We aimed to correlate the ONSD obtained by ultrasonography (USG) with the ONSD obtained by magnetic resonance imaging (MRI) and to find its measurement accuracy.
Methodology: A prospective double-blind study was carried out by performing ocular ultrasounds on 32 patients with clinical features of intracranial hypertension.
Management of Unruptured Infectious Intracranial Aneurysms in Infective Endocarditis: A Case Report and Literature Review.
Cureus
December 2024
Department of Neurosurgery, International University of Health and Welfare Narita Hospital, Narita, JPN.
Infectious intracranial aneurysms (IIAs) are rare lesions with fragile arterial walls located within the aneurysms, carrying a high risk of rupture. Standard management often involves antibiotic therapy and parent artery occlusion; however, the latter carries a significant risk of cerebral infarction. This report presents a case of an unruptured IIA following cerebral infarction, successfully treated with coil embolization while preserving the parent artery.
View Article and Find Full Text PDFAnesthesia for the Pregnant Patient Undergoing Intracranial Procedures.
J Neurosurg Anesthesiol
January 2025
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia.
This focused review explores the current literature on anesthetic care of pregnant patients requiring intracranial intervention. Neuropathology in pregnancy is rare, and existing evidence for management remains limited by the ethical complexities surrounding maternal and fetal research-related risks; pregnant women are typically excluded from randomized controlled trials. Physiological changes during pregnancy, combined with additional fetal considerations, alter pharmacodynamics and complicate the safety profile of maternal interventions.
View Article and Find Full Text PDFStereotactic injection of murine brain tumor cells for neuro-oncology studies.
Methods Cell Biol
January 2025
Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, United States. Electronic address:
Glioblastomas (GBMs) are the most common and aggressive brain tumors, with a poor prognosis. Effective preclinical models are crucial to investigate GBM biology and develop novel treatments. Syngeneic models, which consist in injecting murine GBM cells into mice with a similar genetic background, offer reproducibility, cost-effectiveness, and an intact immune system, making them ideal for immunotherapy research.
View Article and Find Full Text PDFCharacterization of RAP Signal Patterns, Temporal Relationships, and Artifact Profiles Derived from Intracranial Pressure Sensors in Acute Traumatic Neural Injury.
Sensors (Basel)
January 2025
Department of Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Goal: Current methodologies for assessing cerebral compliance using pressure sensor technologies are prone to errors and issues with inter- and intra-observer consistency. RAP, a metric for measuring intracranial compensatory reserve (and therefore compliance), holds promise. It is derived using the moving correlation between intracranial pressure (ICP) and the pulse amplitude of ICP (AMP).
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