A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele.

Sex Transm Dis

From the *CDC Division of STD Prevention, Atlanta, GA; †Oklahoma State Department of Health, HIV/STD Service, Oklahoma City, OK; and ‡Texas Department of State Health Services, Laboratory Services Section, Austin, TX.

Published: August 2017

We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932624PMC
http://dx.doi.org/10.1097/OLQ.0000000000000645DOI Listing

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