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Relaxivity and In Vivo Human Performance of Brand Name Versus Generic Ferumoxytol.

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From the Department of Radiology, University of Wisconsin-Madison, Madison, WI (R.A.V., D.T., J.R., S.B.R.); Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (R.A.V.); Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI (L.M.); Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI (J.R.); Department of Medical Physics, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.); and Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.).

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Correction : The synthesis of size-adjustable superparamagnetism FeO hollow microspheres.

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Adsorption of DNA fluorescent probes on GO-FeO is a promising strategy for establishing fluorescent bioassays, often using magnetic separation or fluorescence quenching to generate signals. However, there is a lack of systematic understanding of ssDNA-regulated changes in the enzyme-mimetic activity of GO-FeO, and the accuracy of the results of single-mode fluorescence analysis is susceptible to environmental interference. These limit the rational design and scope of application of the methods.

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