Objective: Review the multiparametric MRI (mpMRI) findings of transition zone (TZ) prostate cancer (PCa) using T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) MRI and to integrate mpMRI findings with clinical history, laboratory values, and histopathology.
Conclusion: TZ prostate tumors are challenging to detect clinically and at MRI. mpMRI using the combination of sequences has the potential to improve accuracy of TZ cancer detection and staging.
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http://dx.doi.org/10.1007/s00261-017-1184-6 | DOI Listing |
We report on the growth of a 2.86 at.% Ho:YGG crystal using the optical floating zone technique in an oxygen-rich environment, followed by the study of its structure, optical spectroscopy and first demonstration of continuous-wave laser operation at 2.
View Article and Find Full Text PDFNat Rev Urol
January 2025
Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Anterior prostate cancers (APCs) are a group of impalpable neoplasms located in regions anterior to the urethra, which comprise the transition zone, apical peripheral zone and anterior fibromuscular stroma. These regions are typically undersampled using conventional biopsy schemes, leading to a low detection rate for APC and a high rate of false negatives. Radical prostatectomy series suggest prevalence rates of at least 10-30%, but transperineal systematic biopsy is ideal for diagnosis, particularly where multiparametric MRI is unavailable.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Henan University of Technology, School of Chemistry and Chemical Engineering, CHINA.
Developing of molecular crystalline materials with light-induced multiple dynamic deformation in space dimension and photochromism on time scales has attracted much attention for its potential applications in actuators, sensoring and information storage. Nevertheless, organic crystals capable of both photoinduced dynamic effects and static color change are rare, particularly for multi-component cocrystals system. In this study, we first report the construction of charge transfer co-crystals allows their light-induced solid-to-liquid transition and photochromic behaviors to be controlled by trans-stilbene (TSB) as an electron donor and 3,4,5,6-Tetrafluorophthalonitrile (TFP) as an electron acceptor.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, No.2, Xihuan South Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing, China.
Spirometry findings, such as restrictive spirometry and airflow obstruction, are associated with renal outcomes. Effects of spirometry findings such as preserved ratio impaired spirometry (PRISm) and its trajectories on renal outcomes are unclear. This study aimed to investigate the impact of baseline and trajectories of spirometry findings on future chronic kidney disease (CKD) events.
View Article and Find Full Text PDFActa Biomater
January 2025
Biomedical Engineering, College of Engineering, Mathematics and Physical Sciences, University of Exeter, UK. Electronic address:
The biomechanical properties of articular cartilage arise from a complex bioenvironment comprising hierarchically organised collagen networks within the extracellular matrix (ECM) that interact with the proteoglycan-rich interstitial fluid. This network features a depth-dependent fibril organisation across different zones. Understanding how collagen fibrils respond to external loading is key to elucidating the mechanisms behind lesion and managing degenerative conditions like osteoarthritis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!