A new and convenient strategy for the preparation of metallosomes has been developed by mixing organometallic metallosurfactants and phospholipids. These aggregates show the characteristic properties of liposomes (stability upon dilution and low toxicity) and the toxicity is at least ten-fold lower than that of the metallosurfactant aggregates without phospholipids.
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Metallosurfactant aggregates: Structures, properties, and potentials for multifarious applications.
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Metallosurfactants offer important scientific and technological advances due to their novel interfacial properties. As a special class of structures formed by the integration of metal ions into amphiphilic surfactant molecules, these metal-based amphiphilic molecules possess both organometallic and surface chemistries. This review critically examines the structural transitions of metallosurfactants from micelle to vesicle upon metal coordination.
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Research Institute for Chemical Process Technology, National Institute of Advanced Industrial Science and Technology (AIST).
Metallosurfactants are emerging as a relatively new class of surfactants whose ligand moieties bind to various transition metals. Because transition metal centers are incorporated into the surfactant frameworks, they can form various self-assembled structures with metallic interfaces such as micelles, vesicles, and lyotropic liquid crystals. To reduce the lability of transition metal complexes under aqueous conditions, various amphiphilic ligands have been developed as surfactant frameworks.
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Inorg Chem
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Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Str., 420088 Kazan, Russia.
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Dalton Trans
October 2018
Biophysics Unit/Center for Biophysical Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autònoma de Barcelona, Avda. de Can Domènech, 08193 Cerdanyola, Spain.
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