The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis. There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration. Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487515 | PMC |
| http://dx.doi.org/10.3389/fnbeh.2017.00124 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: A proof-of-concept study.
Clin Neurophysiol
November 2024
Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016, USA; Center for Human Neuroscience Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016, USA; Center for Health Behaviors Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24016, USA; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA; Graduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, VA 24016, USA; Department of Neurosurgery, Carilion Clinic, Roanoke, VA 24016, USA. Electronic address:
Article Synopsis
- The study investigates how focused ultrasound (LIFU) can modify brain responses tied to heartbeat, known as heartbeat evoked potentials (HEP), and focuses on specific brain regions like the insula and dorsal anterior cingulate cortex (dACC).
- Healthy participants received targeted LIFU while their brain activity (EEG) and heart activity (ECG) were monitored, with the main goal of observing changes in HEP amplitudes.
- Results showed that LIFU to the posterior insula reduced HEP amplitudes, but it did not alter heart rate or variability, indicating the potential for targeting brain areas to influence interoceptive processing.
Temporal-spatial deciphering mental subtraction in the human brain.
Cogn Neurodyn
June 2024
Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, 100053 Beijing, China.
Unlabelled: Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or functional magnetic resonance imaging to resolve the structure pattern and functional activity during subtraction operation. However, a high resolution of the spatial-temporal understanding of the neural mechanisms involved in mental subtraction is unavailable.
View Article and Find Full Text PDFBackground: The heartbeat evoked potential (HEP) is a brain response time-locked to the heartbeat and a potential marker of interoceptive processing. The insula and dorsal anterior cingulate cortex (dACC) are brain regions that may be involved in generating the HEP. Low-intensity focused ultrasound (LIFU) is a non-invasive neuromodulation technique that can selectively target sub-regions of the insula and dACC to better understand their contributions to the HEP.
View Article and Find Full Text PDFBidirectional relationship between insular grey matter volume and alexithymia: Evidence from a longitudinal study.
J Affect Disord
October 2023
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, China; Faculty of Education, Southwest University, Chongqing, China. Electronic address:
Background: The insula is considered to be involved in emotional cognitive processes, and may be structurally altered in people with alexithymia. However, it remains unclear how the relationship between the insula and alexithymia changes over time. This study aimed to investigate whether alexithymia has longitudinal relationship with the insular structure.
View Article and Find Full Text PDFDRD2 TaqIA polymorphism-related functional connectivity between anterior insula and dorsolateral prefrontal cortex predicts the retention time in heroin-dependent individuals under methadone maintenance treatment.
Eur Arch Psychiatry Clin Neurosci
March 2024
Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, People's Republic of China.
Background: Dopamine receptor D2 (DRD2) TaqIA polymorphism has an influence on addiction treatment response and prognosis by mediating brain dopaminergic system efficacy. Insula is crucial for conscious urges to take drugs and maintain drug use. However, it remains unclear about the contribution of DRD2 TaqIA polymorphism to the regulation of insular on addiction behavioral and its relation with the therapeutic effect of methadone maintenance treatment (MMT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!