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Article Abstract
Objective: To measure the effect of buprenorphine-naloxone as opioid substitution therapy on glycemic control in patients with type 2 diabetes mellitus and opioid use disorder.
Design: Retrospective cohort study and secondary data analysis.
Setting: Northwestern Ontario.
Participants: Patients with diabetes receiving opioid substitution therapy, as well as patients with diabetes only, who live in 6 remote First Nations communities.
Main Outcome Measures: Glycated hemoglobin A values during a 2-year time period in the 2 groups.
Results: Over a 2-year period, there was an absolute decrease of 1.20% in mean glycated hemoglobin A values in patients with diabetes who also received opioid substitution therapy, compared with patients with diabetes who were not being treated for opioid dependence, whose values rose by 0.02%.
Conclusion: Patients with diabetes who also suffer from opioid use disorder achieve significant ( = .011) improvement in glycemic control when treated with buprenorphine-naloxone substitution therapy compared with other patients with diabetes. Treating opioid use disorder with buprenorphine-naloxone substitution therapy has an unintended positive effect on diabetes management.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507246 | PMC |
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