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| http://dx.doi.org/10.5935/abc.20170066 | DOI Listing |
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Prognostic Implications of Cardiac Geometry in Cirrhosis: Findings From a Large Cohort.
Liver Int
February 2025
General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Background And Aims: Cirrhosis is characterised by hyperdynamic circulation, which contributes to cirrhotic cardiomyopathy (CCM). However, the expert consensus on CCM did not initially include cardiac structure because of scant evidence. Therefore, this study investigated the associations of cardiac chamber geometry with mortality and CCM.
View Article and Find Full Text PDFThe Cardiomyocyte in Cirrhosis: Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy.
Rev Cardiovasc Med
December 2024
Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Article Synopsis
- Cirrhotic cardiomyopathy is characterized by both systolic and diastolic dysfunction in patients with cirrhosis, resulting from abnormalities in heart muscle cells (cardiomyocytes) without any underlying heart disease.
- Changes at the cellular level include altered membrane fluidity and dysfunctional receptors (like beta-adrenergic), as well as issues with calcium and ion transport processes, impacting overall heart function.
- The heart in cirrhotic patients also undergoes fibrotic changes similar to those in the liver, leading to stiffness and further dysfunction, compounded by excessive cell death of cardiomyocytes.
Post-Transjugular Intrahepatic Portosystemic Shunt Right Atrial Pressure and Left Atrial Volume Index Predict Heart Failure and Mortality: Dual Center Experience.
Am J Gastroenterol
November 2024
Division of Gastroenterology and Hepatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Article Synopsis
- Heart failure (HF) after transjugular intrahepatic portosystemic shunt (TIPS) affects up to 20% of cirrhotic patients, making it crucial to identify risk factors for better outcomes.
- A retrospective study on 360 cirrhotic patients found that elevated right atrial pressure during TIPS and an increase in left atrial volume index within 180 days post-TIPS were linked to higher risks of HF and mortality, respectively.
- The findings suggest that while cirrhotic cardiomyopathy status alone isn't predictive, monitoring echocardiographic changes could help identify patients at greater risk for complications after TIPS.
Association Between Sleep Quality and Cirrhotic Cardiomyopathy: A Prospective Case-Control Study.
Nat Sci Sleep
December 2024
Department of General Surgery, People's Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212002, People's Republic of China.
Objective: The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).
Methods: The study included liver cirrhosis patients aged 18-75 from Northern Jiangsu People's Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.
Results: The study found that the onset of CCM was not related to the etiology of inducing cirrhosis.
The role and mechanism of P2X7R in cirrhotic cardiomyopathy.
Mol Immunol
December 2024
Wuxi Medical Center, Nanjing Medical University, Wuxi, China; The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China; Wuxi People's Hospital, Wuxi, China. Electronic address:
In the context of liver cirrhosis, the incidence of myocardial inflammation and apoptosis escalates, contributing to the development and progression of cirrhotic cardiomyopathy. The P2X7 receptor, a purinergic receptor linked to inflammatory processes, has been identified in the etiology of a range of autoinflammatory, autoimmune, chronic inflammatory, and metabolic disorders. Despite this, the specific role of the P2X7 receptor in the etiology of cirrhotic cardiomyopathy remains to be elucidated.
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