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Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels. | LitMetric

Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels.

Adv Healthc Mater

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.

Published: September 2017

AI Article Synopsis

Article Abstract

Ideal bone scaffolds having good biocompatibility, good biodegradability, and beneficial mechanical properties are the basis for bone tissue engineering. Specifically, cell migration within 3D scaffolds is crucial for bone regeneration of critical size defects. In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze-casting (ice-templating) method. While most studies promote cell migration by chemical factors, it can be greatly enhanced by introducing only graded channels as compared with tortuous or parallel channels. The results provide insights and guidance in designing novel scaffolds to enhance cell migration behavior for bone tissue regeneration.

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201700472DOI Listing

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