Historically, effort has been viewed as aversive. Most supporting evidence comes from studies demonstrating increased force/effort requirements reduce operant responding. Changes in force/effort requirements, however, are often accompanied by changes in response definition when mechanical devices are used to define the response. As a consequence, responses measured at one point in a study may go unmeasured at other points. In an alternative approach, we used a continuous measurement strategy that provided a means to fix the threshold force defining the response class and simultaneously allowed independent manipulation of the force criteria required to produce reinforcement. Rats pressed a force transducer according to a fixed-ratio 5 schedule of food delivery. The criterion force was systematically increased and decreased; the threshold for response detection was constant. When response rates included only criterion responses, overall rate decreased when force requirements increased. By contrast, when all responses, both those meeting force criteria and those that did not (above the threshold but below the criteria for reinforcement) were included in the rate calculation, increases in force increased response rate. Increases in force criteria also increased the maximum force (g) and time-integral of force (g-s) of operant behavior. Control conditions showed increases in responding could be explained by the emergence of subcriterion responses, irrespective of force. We conclude that prior results showing effort decreases response rates are due to an artifact arising from inadvertent changes in response definitions. Increases in effort may better be understood as changes in the response:reinforcer payoff owing to the emergence of a subcriterion response class.
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Sci Rep
January 2025
Department of Military Traffic Injury Prevention and Control, Daping Hospital, Army Medical University, No. 10 Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
The incidence of blast injuries has been rising globally, particularly affecting the lungs due to their vulnerability. Primary blast lung injury (PBLI) is associated with high morbidity and mortality rates, while early diagnostic methods are limited. With advancements in medical technology, and portable handheld ultrasound devices, the efficacy of ultrasound in detecting occult lung injuries early remains unclear.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Department of Integrative Physiology, University of Colorado Boulder.
Our purpose was to compare the influence of the spectral content of motor unit recordings on the calculation of electromechanical delay and on the prediction of force fluctuations from measures of the variability in discharge times and neural drive during steady isometric contractions with the first dorsal interosseus muscle. Participants ( = 42; 60 ± 13 yrs) performed contractions at 5% and 20% MVC. After satisfying inclusion criteria, high-density surface EMG recordings from a subset of 23 participants were decomposed into the discharge times of 530 motor units.
View Article and Find Full Text PDFCureus
December 2024
Family Medicine, Najran Armed Forces Hospital, Najran, SAU.
Although observational studies have linked vitamin D deficiency to diabetes, it is unknown if taking vitamin D supplements can reduce the chance of developing type 2 diabetes mellitus (T2DM). The purpose of this systematic review is to determine whether vitamin D supplementation lowers the risk of type 2 diabetes. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to search for studies based on pre-established inclusion and exclusion criteria.
View Article and Find Full Text PDFCureus
January 2025
General Practice, Wad Medani Hospital, Wad Medani, SDN.
To enhance patient outcomes in pediatric cancer, a better understanding of the medical and biological risk variables is required. With the growing amount of data accessible to research in pediatric cancer, machine learning (ML) is a form of algorithmic inference from sophisticated statistical techniques. In addition to highlighting developments and prospects in the field, the objective of this systematic study was to methodically describe the state of ML in pediatric oncology.
View Article and Find Full Text PDFJ Gastric Cancer
January 2025
Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Gastric cancer is one of the most common cancers in both Korea and worldwide. Since 2004, the Korean Practice Guidelines for Gastric Cancer have been regularly updated, with the 4th edition published in 2022. The 4th edition was the result of a collaborative work by an interdisciplinary team, including experts in gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology, and guideline development methodology.
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