We show the vertebrate anterior -posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox-Hox interactions. 4/ 'Decision points' involving signalling pathways separate axial domains.
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A tribute to D'Arcy Wentworth Thompson: Elucidation of a developmental principle.
Bioessays
August 2017
Sylvius Laboratory, Institute of Biology, University of Leiden, Leiden, The Netherlands.
We show the vertebrate anterior -posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head.
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