AI Article Synopsis

  • Patients with rheumatoid arthritis (RA) experience higher oxidative stress and lower antioxidant levels, prompting researchers to examine the effects of different cold treatments on their antioxidant capacity.
  • Sixty RA patients were randomly assigned to whole body cryotherapy at either -110 °C, -60 °C, or local cryotherapy, receiving treatment three times a day for a week.
  • The study found that while whole body cryotherapy at -110 °C led to a significant short-term increase in antioxidant capacity after the first session, other treatments did not show significant changes over time, indicating that the benefits of cold treatments may be limited and transient.

Article Abstract

Patients with rheumatoid arthritis (RA) have increased oxidative stress, decreased antioxidant levels, and impaired antioxidant capacity. Cold treatments are used to relieve joint inflammation and pain. Therefore, we measured the effect of cold treatments on the antioxidative capacity of RA patients with active disease. Sixty patients were randomized to (1) whole body cryotherapy at -110 °C, (2) whole body cryotherapy at -60 °C, or (3) local cryotherapy. Each treatment was given three times daily for 7 consecutive days in addition to the conventional rehabilitation. Blinded rheumatologist evaluated disease activity before the first and after the last cryotherapy. We collected plasma samples daily immediately before the first and after the second cryotherapy and measured total peroxyl radical trapping antioxidant capacity of plasma (TRAP), which reflects global combined antioxidant capacity of all individual antioxidants in plasma. Baseline morning TRAP levels (mean, 95% CI), adjusted for age, body mass index, disease activity, and dose of prednisolone, were 1244 (1098-1391) µM/l in the local cryotherapy, 1133 (1022-1245) µM/l in the cryotherapy at -60 °C, and 989 (895-1082) µM/l in the cryotherapy at -110 °C groups (p = 0.006). After the first treatment, there was a rise in 1-h TRAP of 14.2 (-4.2 to 32.6) µM/l, 16.1 (-7.4 to 39.6) µM/l, and 23.6 (4.1-43.2) µM/l, respectively. The increase was significant in the whole-body cryotherapy -110 °C group (p < 0.001) but not significant between the groups (p = 0.78). When analyzed for the whole week, the daily morning TRAP values differed significantly between the treatment groups (p = 0.021), but there was no significant change within each treatment group. Whole-body cryotherapy at -110 °C induced a short-term increase in TRAP during the first treatment session with but not during other treatment modalities. The effect was short and the cold treatments did not cause a significant oxidative stress or adaptation during 1 week.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-017-3771-9DOI Listing

Publication Analysis

Top Keywords

antioxidant capacity
12
cryotherapy -110 °c
12
cryotherapy
10
antioxidative capacity
8
capacity patients
8
patients active
8
rheumatoid arthritis
8
cold treatments
8
body cryotherapy
8
cryotherapy -60 °c
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!