AI Article Synopsis
- Pluripotency reprogramming and transdifferentiation, driven by transcription factors, can create induced pluripotent stem cells and other specialized cells, but their effectiveness is hampered by reintroducing external genes.
- Small molecules targeting various biological processes have emerged as tools to enhance the efficiency of cell induction and replace the need for exogenous genes, sometimes achieving cell fate conversion on their own.
- This text reviews recent developments and challenges in using small molecules for generating new cell types from somatic cells, both in laboratory settings and potentially in clinical applications.
Article Abstract
Pluripotency reprogramming and transdifferentiation induced by transcription factors can generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the induction efficiency and the reintroduction of exogenous genes limit their translation into clinical applications. Small molecules that target signaling pathways, epigenetic modifications, or metabolic processes can regulate cell development, cell fate, and function. In the recent decade, small molecules have been widely used in reprogramming and transdifferentiation fields, which can promote the induction efficiency, replace exogenous genes, or even induce cell fate conversion alone. Small molecules are expected as novel approaches to generate new cells from somatic cells in vitro and in vivo. Here, we will discuss the recent progress, new insights, and future challenges about the use of small molecules in cell fate conversion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107793 | PMC |
| http://dx.doi.org/10.1007/s00018-017-2586-x | DOI Listing |
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