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Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach. | LitMetric

AI Article Synopsis

  • Chronic myeloid leukemia (CML) is a cancer of blood stem cells caused by the BCR-ABL1 fusion protein, which results from a specific chromosomal translocation known as the Philadelphia chromosome.
  • Monitoring patient outcomes in CML often involves quantitative real-time PCR to assess the presence of the BCR-ABL1 fusion.
  • Targeting the BCR-ABL1 fusion kinase represents a groundbreaking approach in molecularly targeted therapies for effectively treating CML.

Article Abstract

Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q:q). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503218PMC
http://dx.doi.org/10.15430/JCP.2017.22.2.74DOI Listing

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