Background: Blood stream infections (BSIs) represent a major complication of allo-SCT and are a major cause of morbidity and mortality during and after bone marrow aplasia.
Objectives: The objective of this study was to describe the incidence and outcome of BSIs in a cohort of patients submitted to allo-SCT, in order to track changes of the epidemiology and bacteria resistance.
Methods: We retrospectively analyzed the microbiological data of 162 patients allotransplanted in Brescia University Hospital, over a period of 6 years.
Results: Eighty patients experienced a BSIs for a total of 119 isolates. In 77 cases (65%) a Gram positive bacteria was isolated, being coagulase negative the most frequent species (77% of the cases). In 42 cases (35%) a Gram negative bacteria was isolated (. 57% and P. 24%). Fluoroquinolones resistance was frequent (90% for , 92% for E. , 90% for ). Methycillin resistance of was 100%, 76% of were ESBL positive and among resistance to carbapenems was 40%. The 2 years overall survival of patients with BSIs patients without BSIs was 46% vs 60% (HR1,48, p=0,07). and were the species with the highest mortality (50% and 33%, respectively).
Conclusions: These data confirm that BSIs, mainly sustained by Gram positive bacteria, are frequent in allotransplanted patients (50% of the cases) and may influence the outcome of allotransplanted patients, being antibiotics resistance highly frequent among these bacteria.
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| http://dx.doi.org/10.4084/MJHID.2017.036 | DOI Listing |
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