Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869859 | PMC |
| http://dx.doi.org/10.1042/EBC20160087 | DOI Listing |
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