Alzheimer's disease (AD) is a developmental neurodegenerative disorder for which there is no effective treatment or cure at present. In this study, the neuroprotective properties of a methanol extract of the leaves of Kigelia africana (KAE) and its flavonoid-rich fraction (FKAE) in aluminum chloride (AlCl)-induced experimental AD was evaluated. Symptoms mimicking AD were induced in male Sprague Dawley rats by administering 17mg/kg AlCl, orally, for six consecutive weeks. Pretreatment of animals with 50 and 100mg/kg KAE or FKAE for two weeks, followed by their co-administration with AlCl for a further four weeks ameliorated neurological deficits, cerebral oxidative stress, neurochemical disturbances and histoarchitectural alterations caused by AlCl intoxication. The results suggest that KAE and FKAE are promising therapeutic agents for AD.
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http://dx.doi.org/10.1016/j.pathophys.2017.06.001 | DOI Listing |
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