AI Article Synopsis
- Current diabetic foot ulcer treatments mainly target bacterial biofilms and often overlook fungi.
- A study used a biofilm model that included both bacteria and fungi to assess how different antimicrobials affected the biofilm.
- It was found that using just one type of antimicrobial had little effect on the total biofilm amount, but combining antibiotics specific to both bacteria and fungi successfully reduced the biofilm load.
Article Abstract
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571281 | PMC |
| http://dx.doi.org/10.1128/AAC.00672-17 | DOI Listing |
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