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Cardiovascular effects of histamine in three widely diverse species of reptiles. | LitMetric

Cardiovascular effects of histamine in three widely diverse species of reptiles.

J Comp Physiol B

Zoophysiology, Department of Bioscience, Aarhus University, C.f. Møllers Allé 3, Building 1131, 8000, Aarhus C, Denmark.

Published: January 2018

AI Article Synopsis

Article Abstract

The cardiovascular system of vertebrates is regulated by a vast number of regulatory factors, including histamine. In pythons, histamine induces a strong tachycardia and dilates the systemic vasculature, which resembles the cardiovascular response to the elevated metabolic rate during digestion. In fact, there is an important role of increased histaminergic tone on the heart during the initial 24 h of digestion in pythons. Whilst the cardiovascular effects of histamine are well studied in pythons, little is known about the effects in other groups of reptiles. The histaminergic effects on the heart vary among species and histamine may exert either pressor and depressor effects by causing either constrictive or dilatory vascular responses. Here, we investigated the cardiovascular effects of histamine in three species of reptiles with very different cardiovascular and pulmonary morphologies. Experiments were performed on both anesthetized and recovered animals. We show a species-dependent effect of histamine on the systemic vasculature with dilation in rattlesnakes and constriction in turtles and caimans but no effect on the pulmonary circulation. The histamine-induced dilation in rattlesnakes was mediated through an activation of H-receptors, whereas the histamine-induced constriction in caimans was mediated through both adrenergic signaling and H-receptors activation. In all three species, histamine-induced tachycardia by direct stimulation of histaminergic receptors as well as an indirect activation of adrenoreceptors. This finding highlights a more complex mechanism underlying the action of histamine than previously recognized in reptiles.

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Source
http://dx.doi.org/10.1007/s00360-017-1108-3DOI Listing

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