Previously transgenic plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing extracts containing CecP1 as a candidate drug for treatment of wounds infected with The drug constitutes the whole juice from leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the first time. However, a favorable therapeutic effect of the transgenic extract was attributed to a synergism between the fungicide activity of CecP1 and wound healing (antiscar), revascularizing, and immunomodulating effect of natural biologically active components of . A commercial fungicide preparation clotrimazole eliminated cells within infected wounds in rats with efficiency comparable to CecP1-enriched extract. But in contrast to extract, clotrimazole did not exhibit neither wound healing activity nor remodeling of the scar matrix. Taken together, our results allow assumption that CecP1-enriched extracts should be considered as a candidate drug for treatment of dermatomycoses, wounds infected with fungi, and bedsores.
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| http://dx.doi.org/10.1155/2017/3940743 | DOI Listing |
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