This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C and C tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571731 | PMC |
| http://dx.doi.org/10.1039/c7cc03235h | DOI Listing |
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