Speech errors and naming latencies provide two complementary sets of behavioural data for understanding language production processes. A recent analytical trend-applied to intact and impaired production alike-highlights a link between specific features of correct picture naming latency distributions and the retrieval processes thought to underlie them. Although chronometric approaches to language production typically consider correct response times in isolation, adequately accounting for their distributions in error-prone situations requires also considering the errors that sometimes censor them. In this paper, I illustrate by simulation how excluding incorrect word retrievals predictably alters observed distributions of correct naming latencies. To the extent that naming errors impose a stochastic deadline on successful production, their censoring should tend to reduce the mean, variance, and skew of observed latencies for correct responses, relative to the uncensored underlying distribution.
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http://dx.doi.org/10.1080/02643294.2017.1338563 | DOI Listing |
BMC Health Serv Res
January 2025
Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC "Karaganda Medical University", 40, Gogolya St, Karaganda, 100000, Kazakhstan.
Background: Kazakhstan inherited the Semashko health system model, known for the centralized adoption of rules at the Ministry of Health (MoH) level that regulate the healthcare system. In 2019 MoH established a national framework with indicators aimed at collecting qualitative and quantitative data from healthcare organizations as part of their annual self-evaluation, and biannual external evaluation by the National Research Center for Health Development (NRCHD). The purpose of this study was to pilot the MoH framework on rational use of medicines and evaluate its effects on medicine use practices in health care organizations and at the national level.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Healthy Aging & Alzheimer's Research Care (HAARC) Center, Healthy Aging & Alzheimer's Research Care (HAARC) Center, The University of Chicago, Chicago, IL, USA.
Background: Memory decline in late life is a common hallmark of aging, yet SuperAgers are individuals age 80+ with episodic memory performances at least as good as cognitively average 50-to-60-year-olds. Recent work, combining anatomical and functional MRI, has shown the precise boundaries of large-scale resting state networks vary at the individual level. Further, the use of person-specific rather than standard parcellations has led to more behaviorally meaningful associations, and has not been explored in SuperAgers.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: Diffusion MRI (dMRI) metrics of brain microstructure offer valuable insight into Alzheimer's disease (AD) pathology; recent reports have identified dMRI metrics that (1) tightly link with CSF or PET measures of amyloid and tau burden; and (2) mediate the relationship between CSF markers of AD and delayed logical memory performance, commonly impaired in early AD [1,2]. To better localize white matter tract disruption in AD, our BUndle ANalytic (BUAN) [3] tractometry pipeline allows principled use of statistical methods to map factors affecting microstructural metrics along the 3D length of the brain's fiber tracts. Here, we extended BUAN to pool data from multiple scanning protocols/sites - using a new harmonized tractometry approach, based on ComBat [4,5], a widely-used harmonization method modeling variations in multi-site datasets due to site- and scanner-specific effects.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, Italy.
Background: Current evidence on non-pharmacological treatments in Dementia with Lewy Bodies (DLB) are relatively few and limited by small sample sizes. The goal of this pilot study was to test the efficacy of a new multimodal treatment that combines Tele-Neurorehabilitation and "Bright Light" Therapy (BLT) in a sample of DLB patients.
Method: Eighteen DLB patients (7F; 74.
Alzheimers Dement
December 2024
Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Executive dysfunction is a hallmark clinical feature of frontotemporal degeneration (FTD). Genome-wide association studies have identified genetic variants, and resulting polygenic scores (PGS), related to executive function (EF) in population studies. We evaluated whether EF-PGS correlates with differential rates of cognitive decline in FTD.
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